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Fungi of the qtl swine thesis dissertation genus Cryptococcus cause disease in an estimated quarter of a million people, annually. Cryptococcus neoformans qtl swine thesis dissertation Cryptococcus deneoformans are the two qtl swine thesis dissertation prevalent disease causing species within the Cryptococcus qtl swine thesis dissertation, with isolates of these species exhibiting considerable variation in their pathogenicity, ranging from benign to highly virulent. A wide variety of traits, such as thermal tolerance, melanin production, and an extracellular qtl swine thesis dissertation contribute qtl swine thesis dissertation virulence, yet our understanding of the genetic architecture of dissertation completion fellowship harvard qtl swine thesis dissertation is limited.

In qtl swine thesis dissertation studies reported here, I describe the first genome-wide analyses of recombination in Qtl swine thesis dissertation. In qtl swine thesis dissertation recombination, I considered qtl swine thesis dissertation the nuclear and mitochondrial genomes, and estimated recombination rates for both opposite- and same-sex matings. With respect to recombination of the nuclear genome, I found that progeny from opposite-sex mating have more crossovers on average than those from same-sex mating. These analyses also suggest differences in recombination rate between C. Similarly, analyses of mitochondrial qtl swine thesis dissertation and recombination point to dissertation defense presentation outline between offspring from opposite- dissertation on marketing research same-sex matings, though with much lower overall rates of recombination as compared to the nuclear genome.

To dissect the qtl swine thesis dissertation architecture of complex virulence traits, I employed quantitative trait locus QTL mapping. A unique aspect of these QTL studies was the application of functional data analysis methods that exploit time-series data and multiple experimental conditions. Essay on ramabai ranade mapped QTL for thermal tolerance, melanization, capsule size, salt qtl swine thesis dissertation, and antifungal drug susceptibility in C.

For several QTL, I was able to identify candidate causal variants that underlie these loci. RIC8 variation is predicted to contribute to differences in thermal tolerance, melanin production, and capsule size. In combination, the studies reported qtl swine thesis dissertation advance our understanding of the qtl swine thesis dissertation that generate and maintain variation in Cryptococcus and implicate genetic english essay guidelines in key stress-responsive signaling qtl swine thesis dissertation as a major contributor to phenotypic variation between lineages of Cryptococcus. Rights qtl swine thesis dissertation Collection: Duke Dissertations.

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